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- Title
Prediction of true-negative lymph node metastasis in clinical IA non-small cell lung cancer by measuring standardized uptake values on positron emission tomography.
- Authors
Takenaka, Tomoyoshi; Yano, Tokujiro; Morodomi, Yosuke; Ito, Kensaku; Miura, Naoko; Kawano, Daigo; Shoji, Fumihiro; Baba, Shingo; Abe, Koichiro; Honda, Hiroshi; Maehara, Yoshihiko
- Abstract
Purpose: We developed a method for predicting true-negative lymph node metastases in clinical IA non-small lung cancer (NSCLC) by the combined evaluation of computed tomography (CT), 2-[18F]-fluoro-2-deoxy- d-glucose positron emission tomography (FDG-PET) findings and the maximum standardized uptake value (SUVmax) of primary tumors. Methods: The subjects of this study were 94 patients with clinical stage IA NSCLC who underwent both preoperative CT and FDG-PET. We analyzed the relationship between the SUVmax of primary tumors and various clinicopathological factors to find the best method available for assessing true-negative lymph node metastasis. Results: The pathological stages were IA ( n = 80), IB ( n = 4), IIA ( n = 5), IIIA ( n = 4), and IV ( n = 1). Pathologic lymph node metastasis was recognized in nine patients and the SUVmax of these tumors ranged from 3.3 to 20.3. A SUVmax of 3.0 was defined as the cut-off point and patients were dichotomized according to this point. Tumors with SUVmax of 3.0 or less were associated with a significantly lower incidence of pleural and vascular invasion and were characterized by the degree of differentiation. Conclusion: The SUVmax of primary tumors reflects the grade of malignancy; therefore, the combined evaluation of FDG-PET/CT findings with the SUVmax of primary tumors may help predict lymph node metastasis negativity.
- Subjects
SMALL cell lung cancer; POSITRON emission tomography; DIAGNOSTIC imaging; LYMPH node diseases; LUNG cancer
- Publication
Surgery Today, 2012, Vol 42, Issue 10, p934
- ISSN
0941-1291
- Publication type
Article
- DOI
10.1007/s00595-012-0277-7