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- Title
Efficacy evaluation of a bivalent subunit vaccine against classical swine fever virus and porcine circovirus type 2.
- Authors
Chen, Yu-San; Lee, Chang-Ye; Wu, Chi-Chien; Kao, Pei-Lun; Chen, Tai-An; Huang, Yahui; Chung, Wen-Bin; Kuo, Tsun‑Yung; Chen, Charles
- Abstract
Classical swine fever virus (CSFV) and porcine circovirus type 2 (PCV2) are two of the most devastating and economically significant pathogens affecting pig populations worldwide. Administration of a combination of vaccines against swine pathogens has been demonstrated to be as efficacious as the administration of single vaccines. In this study, we developed and tested a novel bivalent subunit vaccine against CSFV and PCV2. The safety and efficacy of this vaccine were demonstrated in mice and specific pathogen-free (SPF) piglets. In addition to investigating the serological responses after immunization, challenge studies with both viruses were also conducted. The results showed that this CSFV/PCV2 bivalent vaccine elicited a high level of neutralizing antibodies against both viruses and provided protection in challenge studies. In conclusion, the CSFV/PCV2 bivalent vaccine is safe and effective against CSFV or PCV2 challenge.
- Subjects
CLASSICAL swine fever; CLASSICAL swine fever virus; COMBINED vaccines; FEED additives; VACCINE effectiveness; VACCINES
- Publication
Scientific Reports, 2024, Vol 14, Issue 1, p1
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/s41598-024-53624-w