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- Title
Antibacterial activity of grepafloxacin.
- Authors
Wiedemann, B; Heisig, P
- Abstract
Grepafloxacin has an extremely broad spectrum of activity. Its activity against Gram-positive bacteria exceeds that of currently available quinolones. Grepafloxacin-resistant mutants seem to occur less frequently than ciprofloxacin- or ofloxacin-resistant mutants, and the increase in MIC against the former mutants is less than that of the latter. This applies only to the relative differences (in dilution steps); the absolute values are similar. Grepafloxacin kills Gram-positive bacteria at concentrations little above the MIC. Its pharmacodynamic profile against pneumococci is promising, favouring use of this drug for respiratory tract infections.
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 1997, Vol 40, Issue suppl_1, p19
- ISSN
0305-7453
- Publication type
Article
- DOI
10.1093/jac/40.suppl_1.19