We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
MUCOADHESIVE FILMS BASED ON POLYVINYL ALCOHOL AND BIOACTIVE COMPOUNDS FOR ORAL ADMINISTRATION: STRUCTURAL CHARACTERIZATION AND MUCOADHESIVE PROPERTIES.
- Authors
NEAGU, OANA MIHAELA; VICAȘ, LAURA GRAȚIELA; VLASE, ANA-MARIA; VLASE, LAURIAN; PALLAG, ANNAMARIA; TEUȘDEA, ALIN; BÁCSKAY, ILDIKÓ; MARIAN, ELEONORA; MUREȘAN, MARIANA EUGENIA; JURCA, TÜNDE
- Abstract
In this study, two well known plant species, Matricaria chamomilla L. and Viola tricolor L., were characterized in terms of their polyphenolic and antioxidant profiles. 1:1, 1:2 and 2:1 mixtures ratioswere obtained from the alcoholic extracts. The plant extracts were analysed by high performance liquid chromatography coupled with mass spectrometry (HPLC-MS) and by Folin-Ciocâlteu, CUPRAC and DPPH methods. Comparing the values of the bioactive principles contained in each mixture, as well as the antioxidant character, the mixture Matricariae flos/Violae tricolor flos 2:1, with an inhibition percentage of 84.28 ± 1.36%, was chosen to be incorporated into a mucoadhesive polymeric film. The formulated polymeric films were realized by incorporating 5% and 8% polyvinyl alcohol, 5% and 10% plant extract, respectively. The mucoadhesive films pH ranged between the normal salivary pH values (6.899 ± 0.016 and 7.045 ± 0.017), high folding strength and high tensile strength. According to the performed analyses and the plant extract yield operation from the polymer films, the films incorporating 5% polymer and 10% plant extract, respectively 5% polymer and 5% extract exhibited excelent results.
- Subjects
ORAL drug administration; LIQUID chromatography-mass spectrometry; POLYVINYL alcohol; HIGH performance liquid chromatography; BIOACTIVE compounds; DENTAL adhesives
- Publication
Farmacia, 2023, Vol 71, Issue 4, p737
- ISSN
0014-8237
- Publication type
Article
- DOI
10.31925/farmacia.2023.4.9