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- Title
Comparison of diffusion-weighted imaging and MR elastography in staging liver fibrosis: a meta-analysis.
- Authors
Jang, Weon; Jo, Seongil; Song, Ji Soo; Hwang, Hong Pil; Kim, Seong-Hun
- Abstract
Purpose: To compare the diagnostic performance of diffusion-weighted imaging (DWI), gradient-recalled echo-based magnetic resonance elastography (GRE-MRE), and spin-echo echo-planar imaging-based MRE (SE-EPI-MRE) in liver fibrosis staging. Methods: A systematic literature search was done to collect studies on the performance of DWI, GRE-MRE, and SE-EPI-MRE for diagnosing liver fibrosis. Pooled sensitivity, specificity, diagnostic odds ratio, positive and negative likelihood ratio, and a summary receiver operating characteristic (ROC) curve were estimated with a bivariate random effects model. Subgroup analyses on various study characteristics were performed. Results: Sixty studies with a total of 6620 patients were included in the meta-analysis. Pooled sensitivity and specificity of GRE-MRE and SE-EPI-MRE showed high diagnostic accuracy and did not differ significantly. The area under the summary ROC curve for all stages of fibrosis differed significantly between DWI (0.83–0.88) and either GRE-MRE (0.95–0.97) or SE-EPI-MRE (0.95–0.99). Substantial heterogeneity was detected for all three imaging methods. Conclusions: Both GRE-MRE and SE-EPI-MRE are highly accurate for detection of each liver fibrosis stage, with high potential to replace liver biopsy. Although DWI had a moderate accuracy in distinguishing liver fibrosis, it could be regarded as an alternative to MRE, since it is widely available and easily implemented in routine liver MRI.
- Subjects
DIFFUSION magnetic resonance imaging; MAGNETIC resonance imaging; RECEIVER operating characteristic curves; RANDOM effects model; FIBROSIS; ELASTOGRAPHY; GLEASON grading system
- Publication
Abdominal Radiology, 2021, Vol 46, Issue 8, p3889
- ISSN
2366-004X
- Publication type
Article
- DOI
10.1007/s00261-021-03055-2