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- Title
Tumor Immune-Infiltrate Landscape After Chemo-Radiotherapy in a Case Series of Patients with Non-small Cell Lung Cancer: Pretreatment Predictors and Correlation With Outcome.
- Authors
Pavan, Alberto; Ferro, Alessandra; Fortarezza, Francesco; Schiavon, Marco; Evangelista, Laura; Pezzuto, Federica; Lunardi, Francesca; Frega, Stefano; Bonanno, Laura; Rea, Federico; Guarneri, Valentina; Conte, PierFranco; Calabrese, Fiorella; Pasello, Giulia
- Abstract
Introduction Data on tumor immune-milieu after chemo-radiation (CT-RT) are scarce. Noninvasive tools are needed to improve the treatment of non–small cell lung cancer (NSCLC), especially in the locally advanced (LA) setting. Methods We collected a series of superior-sulcus (SS)- patients with NSCLC referred to our Institute (2015-2019), eligible for a preoperative CT-RT. We characterized tumor-infiltrating immune cells (TIICs), determined PD-L1-TPS and the residual viable tumor cells (RVTC). Radiological and metabolic responses were reviewed. We calculated pre-surgery neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR). Results Eight patients were included. Radiological responses were 6 disease stabilities (SD) and 2 partial responses (PR). Metabolic responses were 4 SD and 4 PR. CD68+-TIICs were correlated with metabolic response and lower RVTC. CD68+-TIICs were associated with higher PLR. Higher PLR values seemed linked with lower RVTC. Conclusions These preliminary results could be useful for consolidation treatment selection for patients with LA-NSCLC without evaluable baseline PD-L1 and higher PLR values.
- Subjects
LUNG cancer; PREOPERATIVE care; PLATELET lymphocyte ratio; IMMUNE system; CHEMORADIOTHERAPY; TREATMENT effectiveness; CONTENT mining; NEUTROPHIL lymphocyte ratio; DESCRIPTIVE statistics
- Publication
Oncologist, 2022, Vol 27, Issue 2, pe199
- ISSN
1083-7159
- Publication type
Article
- DOI
10.1093/oncolo/oyab047