We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Clinical features and prognostic factors of patients with cancer-associated stroke.
- Authors
Sawada, Jun; Katayama, Takayuki; Kikuchi-Takeguchi, Shiori; Kano, Kohei; Saito, Masato; Mitsui, Nobuyuki; Hiroshima, Satoru; Kinoshita, Manabu; Nakagawa, Naoki
- Abstract
Background: Cerebrovascular diseases in cancer patients significantly aggravate their condition and prognosis; therefore, prompt and accurate diagnosis and treatment are important. The purpose of this study was to investigate patient demographics, laboratory data, brain magnetic resonance imaging (MRI) findings, and prognosis among patients with stroke and cancer, especially cancer-associated ischemic stroke (CAIS). Methods: We performed a retrospective, single-center study. We enrolled consecutive patients who had acute stroke and were admitted to our hospital between January 2011 and December 2021. We collected general demographic characteristics, cancer histopathological type, laboratory data, brain MRI findings, and prognosis data. Results: Among 2040 patients with acute stroke, a total of 160 patients (7.8%) had active cancer. The types of strokes were cerebral infarction, cerebral hemorrhage, subarachnoid hemorrhage, and transient ischemic attack in 124, 25, 5, and 6 patients, respectively. Among the patients with ischemic stroke, there were 69 cases of CAIS. Pancreas and adenocarcinoma were the most frequent types of primary tumor and histopathology. Patients with adenocarcinoma and those with cerebral infarctions in both bilateral anterior and posterior cerebral circulation areas showed higher D-dimer levels. Pancreatic cancer and high plasma D-dimer levels were associated with poor survival rate. Conclusion: CAIS was seen more frequently in patients with pancreatic cancer and adenocarcinoma. Pancreatic cancer and high plasma D-dimer levels were potential factors of poor prognosis in patients with CAIS.
- Subjects
PROGNOSIS; STROKE patients; CEREBRAL infarction; MAGNETIC resonance imaging; STROKE; CEREBROVASCULAR disease; TRANSIENT ischemic attack
- Publication
Neurological Sciences, 2024, Vol 45, Issue 6, p2747
- ISSN
1590-1874
- Publication type
Article
- DOI
10.1007/s10072-024-07332-y