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- Title
DAPT protects brain against cerebral ischemia by down-regulating the expression of Notch 1 and Nuclear factor kappa B in rats.
- Authors
Li, Shuya; Zhang, Xiangjian; Wang, Yongjun; Ji, Hui; Du, Yuanyuan; Liu, Haichao
- Abstract
Gamma-secretase inhibitor, N-[ N-(3,5-difluorophenacetyl)-1-alanyl]- S-phenylglycine t-butyl ester (DAPT) suppresses the activation of Notch 1 signaling, which is recognized as the cell fate signaling and may participate in inflammatory processes together with NF-κB pathway that contributes to the brain damage after stroke. DAPT has important pharmacological roles in many diseases. However, little is known about the effect of DAPT on NF-κB during cerebral ischemia. This study investigated the time course expression of Notch 1 and the effects of DAPT on Notch 1 and NF-κB after MCAO. The results showed that Notch 1 signaling was up-regulated at the early stage after MCAO, DAPT down-regulated the expression of Notch 1 and NF-κB and protected brain from damage caused by MCAO. These results may indicate that the downregulation of Notch 1-NF-κB pathway after ischemia by administration of DAPT is a potential mechanism for its protection.
- Subjects
CEREBRAL ischemia treatment; INFLAMMATION treatment; PHARMACOLOGY; GENE expression; NF-kappa B; GENETIC regulation; LABORATORY rats
- Publication
Neurological Sciences, 2012, Vol 33, Issue 6, p1257
- ISSN
1590-1874
- Publication type
Article
- DOI
10.1007/s10072-012-0948-6