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- Title
Challenges in the therapeutic approach of a patient with trachea neuroendocrine tumor - case presentation.
- Authors
Rebegea, Laura; Ivan, Iuliana; Crăescu, Mihaela; Firescu, Dorel; Dumitru, Mihaela; Patriche, Gina
- Abstract
Motivation. Neuroendocrine tumors contain a heterogeneous population of tumors, 25% of these being localized in the upper respiratory tract. Materials and method. We present the case of a 52-year-old patient with lung adecarcinoma who performed surgery in 2005. In December 2016 he was histopathologically and immunohistochemically diagnosed with trachea neuroendocrine tumor, Ki67=15%, and positive specific neuroendocrine markers. The patient performed external beam radiotherapy (EBRT) on thoracic target volume, chemotherapy with carboplatin and etoposid, and after that with ocreotid, which was interrupted at his choice. Bone scintigraphy with 99Th revealed secondary bone lesions in December 2017; more suggestive would have been scintigraphy for somatostatin receptors. The treatment with bisphosphonates and EBRT on left iliac bone target volume was initiated. At computed tomography with positron emission (PET-CT), in April 2018, there were evidenced multiple metabolic active lesions: at the 3rd liver segment, soft/hard palate, and skeletal. Discussion and conclusions. There are many questions arising here regarding the starting point of bone metastasis and what would be the therapeutic approach. We present this case due to the rarity of tracheal neuroendocrine carcinoma associated with lung adenocarcinoma, and due to the disease progression and difficulties regarding the therapeutic decision.
- Subjects
NEUROENDOCRINE tumors; CARBOPLATIN; CANCER chemotherapy; THERAPEUTICS; TUMOR treatment
- Publication
Oncolog-Hematolog, 2018, Issue 43, p45
- ISSN
2066-8716
- Publication type
Article