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- Title
Outcome of Children with Acute Lymphoblastic Leukemia Treated with the ALL-BFM 95 Protocol during 2001-2014 at the Pediatric Hematology Center from Tîrgu-Mures.
- Authors
Horvath, Adrienne; Papp, Zsuzsanna Erzsebet; Chincesan, Mihaela; Baghiu, Maria Despina
- Abstract
Survival in childhood acute lymphoblastic leukemia (ALL) has improved substantially during the last years. The aim of the paper is to present the outcome of patients with ALL treated with the ALL-BFM 95 protocol between 20012014 in the Pediatric Clinic from Tirgu-Mures. Eighty-eight newly diagnosed patients with ALL were assessed retrospectively, retrieving data from the clinical records. Kaplan-Meyer survival curves and log-rank analysis were performed with SPSS program. ALL appeared more frequently in males (60,2%) and in the age group 2-5 years (44%). The overall survival (OS) was 72% and the 5-year survival rate of 67,65%. Thirty-two patients had molecular biology tests performed from the bone marrow at diagnosis and two cases had the minor BCR-ABL1 rearrangement. The outcome of the 15 patients with CNS involvement at diagnosis was signifi cantly lower (35,71%) compared to patients without CNS involvement (80,60%) (p= 0.0003). Survival rate was higher in precursor B ALL than in T-cell ALL (76,92% versus 66,67%; p=0.0004). Patients with M1 type BM on the 33rd day (n=72) had an OS of 79,17% compared to the 5 patients with M2 type BM whose OS was only 20% (p=0.0127). Conclusions: Results are improving, yet further efforts are needed to improve outcome.
- Subjects
LYMPHOBLASTIC leukemia in children; CHILDREN'S health; DIAGNOSIS; LEUKEMIA treatment
- Publication
Medicina Moderna, 2016, Vol 23, Issue 3, p196
- ISSN
1223-0472
- Publication type
Article