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- Title
A sellar presentation of a WNT-activated embryonal tumor: further evidence of an ectopic medulloblastoma.
- Authors
Tauziède-Espariat, Arnault; Simbozel, Marie; Liu, Anthony P. Y.; Robinson, Giles W.; Masliah-Planchon, Julien; Sievers, Philipp; Vasiljevic, Alexandre; Duchesne, Mathilde; Puget, Stéphanie; Dangouloff-Ros, Volodia; Boddaert, Nathalie; Métais, Alice; Hasty, Lauren; Dufour, Christelle; Varlet, Pascale
- Abstract
However, a recent study reported 7 cases of WNT-activated embryonal tumors epicentered in the pineal region that clustered within the DNA-methylation class of medulloblastomas, WNT-activated (MB-WNT) [[6]]. Indeed, for this case, there was no tumor in the posterior fossa, and the first biopsy showed a non-tumoral cerebellar parenchyma which may constitute the medulloblastoma cellular origin. The first biopsy of the lesion showed an atrophic cerebellar parenchyma with Purkinje neurons and granular cells (Fig. H Reference DNA methylation classes: medulloblastomas, WNT-activated (MB WNT); medulloblastomas, SHH-activated (MB SHH); medulloblastomas, group 3 (MB G3); medulloblastomas, group 4 (MB G4); pineoblastomas (PB); previously reported embryonal tumors, WNT-activated of the pineal gland (WNT-PB); and the current case.
- Subjects
MEDULLOBLASTOMA; POSTERIOR cranial fossa; INFRATENTORIAL brain tumors
- Publication
Acta Neuropathologica Communications, 2023, Vol 11, Issue 1, p1
- ISSN
2051-5960
- Publication type
Case Study
- DOI
10.1186/s40478-023-01556-3