We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Silymarin in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
- Authors
Voroneanu, Luminita; Nistor, Ionut; Dumea, Raluca; Apetrii, Mugurel; Covic, Adrian
- Abstract
Type 2 diabetes mellitus (T2DM) is associated with increased risk of cardiovascular disease and nephropathy—now the leading cause of end-stage renal disease and dialysis in Europe and the United States. Inflammation and oxidative stress play a pivotal role in the development of diabetic complications. Silymarin, an herbal drug with antioxidant and anti-inflammatory properties, may improve glycemic control and prevent the progression of the complications. In a systematic review and meta-analysis including five randomized controlled trials and 270 patients, routine silymarin administration determines a significant reduction in fasting blood glucose levels (−26.86 mg/dL; 95% CI −35.42–18.30) and HbA1c levels (−1.07; 95% CI −1.73–0.40) and has no effect on lipid profile. Benefits for silymarin on proteinuria and CKD progressions are reported in only one small study and are uncertain. However, being aware of the low quality of the available evidence and elevated heterogeneity of these studies, no recommendation can be made and further studies are needed.
- Subjects
TYPE 2 diabetes; SILYMARIN; CARDIOVASCULAR diseases risk factors; CHRONIC kidney failure; SYSTEMATIC reviews; RANDOMIZED controlled trials
- Publication
Journal of Diabetes Research, 2016, p1
- ISSN
2314-6745
- Publication type
Article
- DOI
10.1155/2016/5147468