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- Title
Analysis of Retinol Binding Protein 4 and ABCA4 Gene Variation in Non-Neovascular Age-Related Macular Degeneration.
- Authors
Chou, Hung-Da; Hwang, Yih-Shiou; Chen, Kuan-Jen; Wu, Wei-Chi; Liu, Laura; Ou, Shyh-Tyan; Liao, Webber; Wang, Cheng-Chi; Lin, Tom; Lai, Chi-Chun
- Abstract
Age-related macular degeneration (AMD) may be associated with ABCA4 variants and is characterized by the accumulation of visual cycle-byproduct lipofuscin. Reducing retinol-binding protein 4 (RBP4), a retinol transporter protein, may reduce lipofuscin production. This study aims to assess the associations between plasma RBP4, the ABCA4 variation, and AMD severity. Sixty-seven participants were grouped into healthy/mild AMD (n = 32) and severe AMD (n = 35) groups. The latter group was older than the former group and had higher levels of RBP4 (36.8 ± 8.3 vs. 30.4 ± 7.0 μg/mL, p = 0.0012). The ten participants with six ABCA4 linked-variants had higher RBP4 than those without (37.8 ± 7.7 vs. 32.4 ± 7.9 μg/mL; p = 0.026), and eight of them had severe AMD. Univariate analyses showed that severe AMD was related to older age (OR, 1.26; 95% CI, 1.13–1.40; p < 0.0001) and to higher RBP4 levels (OR, 1.12; 95% CI, 1.04–1.20; p = 0.003), whereas the linked ABCA4 variants had no associations. After adjustment, however, only age remained significantly associated with severe AMD. This pilot study shows a trend of higher plasma RBP4 levels in severe AMD or the ABCA4-linked variants, and further age-matched studies are warranted.
- Subjects
MACULAR degeneration; VITAMIN A; CARRIER proteins; RETINOL-binding proteins; UNIVARIATE analysis
- Publication
Diagnostics (2075-4418), 2023, Vol 13, Issue 14, p2411
- ISSN
2075-4418
- Publication type
Article
- DOI
10.3390/diagnostics13142411