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- Title
DMBT1 expression in biliary carcinogenesis with correlation of clinicopathological data.
- Authors
Goeppert, Benjamin; Roessler, Stephanie; Becker, Natalia; Zucknick, Manuela; Vogel, Monika N; Warth, Arne; Pathil‐Warth, Anita; Mehrabi, Arianeb; Schirmacher, Peter; Mollenhauer, Jan; Renner, Marcus
- Abstract
Aims Deleted in malignant brain tumours 1 ( DMBT1) exerts functions in the regulation of epithelial differentiation and inflammation and has been proposed as a tumour suppressor. Because chronic inflammation is a hallmark of cholangiocarcinogenesis, the aim of this study was to investigate the expression of DMBT1 in biliary tract cancer ( BTC) and to correlate this expression with clinicopathological data. Methods and results The expression of DMBT1 protein was examined immunohistochemically in 157 BTC patients [41 intrahepatic ( ICC), 60 extrahepatic cholangiocarcinomas ( ECC) and 56 adenocarcinomas of the gallbladder ( GBAC)]. Additionally, 56 samples of high-grade biliary intraepithelial neoplasia (Bil IN 3) and 92 corresponding samples of histological non-neoplastic biliary tract tissues were included. DMBT1 expression was increased significantly in Bil IN 3 compared to normal tissue ( P < 0.0001) and BTC ( P < 0.0001). BTC showed no significant difference in DMBT1 expression compared to non-neoplastic biliary tissue ( P = 0.315). Absent DMBT1 expression in non-neoplastic biliary tissue of BTC patients was associated with poorer survival ( P = 0.027). DMBT1 expression was correlated significantly with patients' age ( P < 0.001). Conclusion DMBT1 is expressed differently in cholangiocarcinogenesis and poorer patients' survival rates are associated with absent DMBT1 expression in non-neoplastic biliary tissue, suggesting a tumour-suppressive role of DMBT1 in early cholangiocarcinogenesis.
- Subjects
BILIARY tract cancer; CHOLANGIOCARCINOMA; TUMOR prognosis; BRAIN tumors; INFLAMMATION
- Publication
Histopathology, 2017, Vol 70, Issue 7, p1064
- ISSN
0309-0167
- Publication type
Article
- DOI
10.1111/his.13175