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- Title
Effects of Maca Extract on Exercise Endurance and Ultrastructure of Mitochondria in Spinal Neurons.
- Authors
Farong YU; Wangjun CHEN; Xiuzhen LIAN; Mingren XEE; Denglou LI; Yuimian GUO
- Abstract
[Objectives] To study the effects of maca extract on the exercise endurance and ultrastructure of mitochondria in spinal neurons. [Methods] First, 50 Wistar rats were randomly divided into 5 groups. The control group; no swimming, administered intragastrically the same volume of distilled water; simple swimming group; free swimming, administered intragastrically the same volume of distilled water; maca extract groups; free swimming, and treated with 4.0, 5.3, and 8.0 g/kg dose of maca extracts. Swimming rats swam freely in the circulating water flow of swimming pool and administered for 15 d. On the 16th d, after the swimming endurance test, the rats were killed painlessly. The ultrastructure of the mitochondria in the spinal neurons was observed with a projection electron microscope, muscle glycogen, malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and free calcium in muscle were measured by radioimmunoassay. [Results] Compared with the simple swimming group, the swimming time before sinking and total swimming time extended 19.83%, 60.28%, 77.55% and 55.34%, 73.91% and 94.47% respectively, and the differences were statistically significant (P < 0.01). The sink-ing times decreased by 34.35%, 51.18% and 57.96% respectively, the differences were statistically significant (P <0.01). MDA and free calcium decreased by 20.10%, 31.49% and 38.72%, respectively with statistically significant differences (P <0.01) and 6.42%, 17.58% and 26.35% respectively. The levels of SOD, GSH-Px and muscle glycogen increased by 5.12%, 22.74%, 52.53%, 44. 22%, 77.79% and 98.45% respectively, with statistically significant differences (P <0.01) and 35.08%, 47.83% and 81.88%, respectively, with statistically significant differences (P <0.01). The volume density (Vd), surface density (Sd) and number density (Nd) of mitochondria of spinal neurons decreased by 7.79%, 18.18%, 31.17%, 16.95%, 27.34%, 43.31% and 13.51%, 23.19% and 43.15% respectively. [Conclusions] Maca extract can protect ultrastructure of the mitochondria in the spinal neurons, antioxidant activity, increase muscle glyco¬gen, and improving the exercise capacity.
- Subjects
SPINAL cord physiology; MACA (Plant); PHYSICAL fitness; MITOCHONDRIAL physiology; THERAPEUTIC use of plant extracts; THERAPEUTICS
- Publication
Medicinal Plant, 2018, Vol 9, Issue 3, p47
- ISSN
2152-3924
- Publication type
Article
- DOI
10.19600/j.cnki.issn2152-3924.2018.03.013