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- Title
Effects of aerobic and resistance training on abdominal fat, apolipoproteins and high-sensitivity C-reactive protein in adolescents with obesity: the HEARTY randomized clinical trial.
- Authors
Alberga, A S; Prud'homme, D; Kenny, G P; Goldfield, G S; Hadjiyannakis, S; Gougeon, R; Phillips, P; Malcolm, J; Wells, G; Doucette, S; Ma, J; Sigal, R J
- Abstract
<bold>Objectives: </bold>To investigate the effects of aerobic training, resistance training, or both on abdominal subcutaneous fat (subcutaneous adipose tissue (SAT)) (deep and superficial), visceral fat (visceral adipose tissue (VAT)), apolipoproteins A-1 and B (ApoA-1, ApoB), ApoB/ApoA-1 ratio and high-sensitivity C-reactive protein (HSCRP) in post-pubertal adolescents with obesity.<bold>Participants: </bold>After a 4-week supervised moderate-intensity exercise run-in period, 304 postpubertal adolescents with overweight (body mass index (BMI) ⩾85th percentile for age and sex+diabetes risk factor) or obesity (⩾95th BMI percentile) aged 14-18 years were randomized to four groups for 22 weeks (5 months): aerobic training, resistance training, combined training or a non-exercising control.<bold>Methods: </bold>This study used a randomized controlled design. All groups received dietary counseling designed to promote healthy eating with a maximum daily energy deficit of 250 kcal. Abdominal fat (SAT and VAT) at the level of the fourth and fifth lumbar vertebrae (L4-L5) was measured by magnetic resonance imaging and ApoA-1, ApoB and HSCRP were measured after a 12-h fast at baseline and after 6 months.<bold>Results: </bold>Changes in SAT at L4-L5 were -16.2 cm(2) in aerobic (P=0.04 vs control), -22.7 cm(2) in resistance (P=0.009 vs control) and -18.7 cm(2) in combined (P=0.02 vs control). Combined training reduced ApoB levels from 0.81±0.02 to 0.78±0.02 g l(-1) (P=0.04 vs control) and ApoB/ApoA-1 ratio from 0.67±0.02 to 0.64±0.02 (P=0.02 vs control and P=0.04 vs aerobic). There were no significant differences in VAT, ApoA-1 or HSCRP levels between groups.<bold>Conclusions: </bold>Aerobic and resistance training and their combination decreased abdominal SAT in adolescents with obesity. Combined training caused greater improvements in ApoB/ApoA-1 ratio compared with aerobic training alone.
- Subjects
CANADA; PREVENTION of childhood obesity; APOLIPOPROTEINS; C-reactive protein; COMPARATIVE studies; EXERCISE; HEALTH promotion; INSULIN resistance; RESEARCH methodology; MEDICAL cooperation; CHILDHOOD obesity; REDUCING diets; RESEARCH; RESEARCH funding; WEIGHT loss; EVALUATION research; BODY mass index; RANDOMIZED controlled trials; TREATMENT effectiveness; ABDOMINAL adipose tissue; RESISTANCE training
- Publication
International Journal of Obesity, 2015, Vol 39, Issue 10, p1494
- ISSN
0307-0565
- Publication type
journal article
- DOI
10.1038/ijo.2015.133