We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Functional Renal Alterations in Chronic Liver Diseases.
- Authors
Gentilini, P.; Laffi, G.; Buzzelli, G.; Stefani, P.; Scarpelli, P.; Paladini, S.; Smorlesi, C.; La Villa, G.; Forti, G.
- Abstract
83 patients with chronic active hepatitis (CAH), 38 of them with cirrhosis, were studied and compared with 10 control subjects suffering from chronic persistent hepatitis (CPH). Tubular acidosis frequently was found in our cases. Renal plasma flow and glomerular filtration rate were significantly decreased in CAH when compared with CPH. Selective renal arteriography showed evident decrease of arterial flow in the outer cortex. Selective renal scan with 99mTc microspheres of human albumin showed a frequent escape of the tracer from the kidney to the lung. PGE1· and PGE2 levels appeared higher in the renal artery than in the vein and were significantly more elevated in 9 cases with cirrhosis vs. 13 controls. These results suggest the frequent functional impairment of the kidney also in the early stages of CAH, with an increase of PGE levels and an opening of intrarenal shunts. Copyright © 1980 S. Karger AG, Basel
- Publication
Digestion, 1980, Vol 20, Issue 2, p73
- ISSN
0012-2823
- Publication type
Article
- DOI
10.1159/000198421