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- Title
Polyfunctional T cell responses are a hallmark of HIV-2 infection.
- Authors
Duvall, Melody G.; Precopio, Melissa L.; Ambrozak, David A.; Jaye, Assan; McMichael, Andrew J.; Whittle, Hilton C.; Roederer, Mario; Rowland-Jones, Sarah L.; Koup, Richard A.
- Abstract
HIV-2 is distinguished clinically and immunologically from HIV-1 infection by delayed disease progression and maintenance of HIV-specific CD4 T cell help in most infected subjects. Thus, HIV-2 provides a unique natural human model in which to investigate correlates of immune protection against HIV disease progression. Here, we report a detailed assessment of the HIV-2-specific CD4 and CD8 T cell response compared to HIV-1, using polychromatic flow cytometry to assess the quality of the HIV-specific T cell response by measuring IFN-γ, IL-2, TNF-α, MIP-1β, and CD107a mobilization (degranulation) simultaneously following Gag peptide stimulation. We find that HIV-2-specific CD4 and CD8 T cells are more polyfunctional that those specific for HIV-1 and that polyfunctional HIV-2-specific T cells produce more IFN-γ and TNF-α on a per-cell basis than monofunctional T cells. Polyfunctional HIV-2-specific CD4 T cells were generally more differentiated and expressed CD57, while there was no association between function and phenotype in the CD8 T cell fraction. Polyfunctional HIV-specific T cell responses are a hallmark of non-progressive HIV-2 infection and may be related to good clinical outcome in this setting.
- Publication
European Journal of Immunology, 2008, Vol 38, Issue 2, p350
- ISSN
0014-2980
- Publication type
Article
- DOI
10.1002/eji.200737768