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- Title
Blood n-3 fatty acid levels and total and cause-specific mortality from 17 prospective studies.
- Authors
Harris, William S.; Tintle, Nathan L.; Imamura, Fumiaki; Qian, Frank; Korat, Andres V. Ardisson; Marklund, Matti; Djoussé, Luc; Bassett, Julie K.; Carmichael, Pierre-Hugues; Chen, Yun-Yu; Hirakawa, Yoichiro; Küpers, Leanne K.; Laguzzi, Federica; Lankinen, Maria; Murphy, Rachel A.; Samieri, Cécilia; Senn, Mackenzie K.; Shi, Peilin; Virtanen, Jyrki K.; Brouwer, Ingeborg A.
- Abstract
The health effects of omega-3 fatty acids have been controversial. Here we report the results of a de novo pooled analysis conducted with data from 17 prospective cohort studies examining the associations between blood omega-3 fatty acid levels and risk for all-cause mortality. Over a median of 16 years of follow-up, 15,720 deaths occurred among 42,466 individuals. We found that, after multivariable adjustment for relevant risk factors, risk for death from all causes was significantly lower (by 15–18%, at least p < 0.003) in the highest vs the lowest quintile for circulating long chain (20–22 carbon) omega-3 fatty acids (eicosapentaenoic, docosapentaenoic, and docosahexaenoic acids). Similar relationships were seen for death from cardiovascular disease, cancer and other causes. No associations were seen with the 18-carbon omega-3, alpha-linolenic acid. These findings suggest that higher circulating levels of marine n-3 PUFA are associated with a lower risk of premature death. Associations between of omega-3 fatty acids and mortality are not clear. Here the authors report that, based on a pooled analysis of 17 prospective cohort studies, higher blood omega-3 fatty acid levels correlate with lower risk of all-cause mortality.
- Subjects
LONGITUDINAL method; OMEGA-3 fatty acids; ALPHA-linolenic acid; DOCOSAHEXAENOIC acid; MORTALITY; EARLY death; CARDIOVASCULAR disease related mortality
- Publication
Nature Communications, 2021, Vol 12, Issue 1, p1
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/s41467-021-22370-2