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- Title
The Drainage of Interstitial Fluid in the Deep Brain is Controlled by the Integrity of Myelination.
- Authors
Aibo Wang; Rui Wang; Dehua Cui; Xinrui Huang; Lan Yuan; Huipo Liu; Yu Fu; Lei Liang; Wei Wang; Qingyuan He; Chunyan Shi; Xiangping Guan; Ze Teng; Guomei Zhao; Yuanyuan Li; Yajuan Gao; Hongbin Han
- Abstract
In searching for the drainage route of the interstitial fluid (ISF) in the deep brain, we discovered a regionalized ISF drainage system as well as a new function of myelin in regulating the drainage. The traced ISF from the caudate nucleus drained to the ipsilateral cortex along myelin fiber tracts, while in the opposite direction, its movement to the adjacent thalamus was completely impeded by a barrier structure, which was identified as the converged, compact myelin fascicle. The regulating and the barrier effects of myelin were unchanged in AQP4-knockout rats but were impaired as the integrity of boundary structure of drainage system was destroyed in a demyelinated rat model. We thus proposed that the brain homeostasis was maintained within each ISF drainage division locally, rather than across the brain as a whole. A new brain division system and a new pathogenic mechanism of demyelination are therefore proposed.
- Subjects
EXTRACELLULAR fluid; MYELINATION; DEEP brain stimulation; CAUDATE nucleus
- Publication
Aging & Disease, 2019, Vol 10, Issue 5, p937
- ISSN
2152-5250
- Publication type
Article
- DOI
10.14336/AD.2018.1206