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- Title
Cholesterol‐dependent cytolysins: The outstanding questions.
- Authors
Johnstone, Bronte A.; Joseph, Riya; Christie, Michelle P.; Morton, Craig J.; McGuiness, Conall; Walsh, James C.; Böcking, Till; Tweten, Rodney K.; Parker, Michael W.
- Abstract
The cholesterol‐dependent cytolysins (CDCs) are a major family of bacterial pore‐forming proteins secreted as virulence factors by Gram‐positive bacterial species. CDCs are produced as soluble, monomeric proteins that bind specifically to cholesterol‐rich membranes, where they oligomerize into ring‐shaped pores of more than 30 monomers. Understanding the details of the steps the toxin undergoes in converting from monomer to a membrane‐spanning pore is a continuing challenge. In this review we summarize what we know about CDCs and highlight the remaining outstanding questions that require answers to obtain a complete picture of how these toxins kill cells.
- Subjects
BACTERIAL proteins; MONOMERS; TOXINS
- Publication
IUBMB Life, 2022, Vol 74, Issue 12, p1169
- ISSN
1521-6543
- Publication type
Article
- DOI
10.1002/iub.2661