We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
UTX/KDM6A suppresses AP-1 and a gliogenesis program during neural differentiation of human pluripotent stem cells.
- Authors
Xu, Beisi; Mulvey, Brett; Salie, Muneeb; Yang, Xiaoyang; Matsui, Yurika; Nityanandam, Anjana; Fan, Yiping; Peng, Jamy C.
- Abstract
Background: UTX/KDM6A is known to interact and influence multiple different chromatin modifiers to promote an open chromatin environment to facilitate gene activation, but its molecular activities in developmental gene regulation remain unclear. Results: We report that in human neural stem cells, UTX binding correlates with both promotion and suppression of gene expression. These activities enable UTX to modulate neural stem cell self-renewal, promote neurogenesis, and suppress gliogenesis. In neural stem cells, UTX has a less influence over histone H3 lysine 27 and lysine 4 methylation but more predominantly affects histone H3 lysine 27 acetylation and chromatin accessibility. Furthermore, UTX suppresses components of AP-1 and, in turn, a gliogenesis program. Conclusions: Our findings revealed that UTX coordinates dualistic gene regulation to govern neural stem cell properties and neurogenesis–gliogenesis switch.
- Subjects
HUMAN stem cells; GENE silencing; GENETIC regulation; GENE expression
- Publication
Epigenetics & Chromatin, 2020, Vol 13, Issue 1, pN.PAG
- ISSN
1756-8935
- Publication type
Article
- DOI
10.1186/s13072-020-00359-3