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- Title
A possible role of repair proteins BRCA1 and DNA-PK in the processing of oxidative DNA damage.
- Authors
Georgakilas, Alexandros G.
- Abstract
BRCA1 and DNA-PK are two significant multifunctional proteins involved primarily in the processing of double strand breaks (DSBs). BRCA1 participates actively in homologous recombination (HR) while DNA-PK in non-homologous end joining (NHEJ). In this mini review, we discuss all recent evidence for a possible involvement of these repair proteins also in the processing of oxidatively-induced DNA damage.
- Subjects
DNA damage; DNA repair; PROTEINS; GENETIC recombination; CHROMOSOMES; OXIDATIVE stress; GENETIC mutation; GENOMES; GENETICS
- Publication
Journal of Biochemical Technology, 2008, Vol 1, Issue 1, p9
- ISSN
0974-2328
- Publication type
Article