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- Title
Case Report A case of a long-time survivor with chronic active Epstein–Barr virus infection.
- Authors
Takeoka, Yasunobu; Nakao, Yoshitaka; Ueda, Misako; Ki-Ryang Koh, Misako; Aoyama, Yasutaka; Nakamae, Hirohisa; Yamamura, Ryousuke; Ohta, Kensuke; Hino, Takayuki; Yamane, Takahisa; Hino, Masayuki; Tokura, Yoshiki; Ishihara, Shigehiko; Oshima, Koichi; Kimura, Hiroshi; Imashuku, Shinsaku
- Abstract
Takeoka Y, Nakao Y, Ueda M, Koh K-R, Aoyama Y, Nakamae H, Yamamura R, Ohta K, Takubo T, Yamane T, Hino M, Tokura Y, Ishihara S, Oshima K, Kimura H, Imashuku S. A case of a long-time survivor with chronic active Epstein–Barr virus infection. Eur J Haematol 2004: 72: 73–76. © Blackwell Munksgaard 2004. Epstein–Barr virus (EBV) is associated with hypersensitivity to mosquito bites (HMB) and fatal EBV-associated hemophagocytic syndrome (HPS). The prognosis of patients with chronic active EBV infection (CAEBV) is very poor. We report a rare case of an adult woman patient with a 28-yr history of HMB, who developed EBV-HPS. EBV genome was detected in the serum and peripheral blood lymphocytes. Clonal proliferation of EBV was demonstrated by Southern blot analysis using an EBV genome terminal-repeat probe. This is a very rare case of a long-term survivor with CAEBV. The patient was initially treated with immunochemotherapy and achieved complete remission. However, the patient immediately relapsed and underwent allogeneic bone marrow transplantation (BMT) from her HLA-matched brother. Peripheral blood cell recovered well, and EBV genome disappeared from the peripheral blood. Allogeneic BMT may be effective in eradicating EBV-HPS. Unfortunately, the patient died of graft vs. host disease on the 92nd day after BMT.
- Subjects
ALLERGIES; EPSTEIN-Barr virus; GENOMES; SERUM; LYMPHOCYTES; DRUG therapy
- Publication
European Journal of Haematology, 2004, Vol 72, Issue 1, p73
- ISSN
0902-4441
- Publication type
Book Review
- DOI
10.1046/j.0902-4441.2004.00164.x