We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
The Novel Role of Platelet-Activating Factor in Protecting Mice against Lipopolysaccharide-Induced Endotoxic Shock.
- Authors
Young-Il Jeong; In Duk Jung; Chang-Min Lee; Jeong Hyun Chang; Sung Hak Chun; Kyung Tae Noh; Soo kyung Jeong; Yong Kyoo Shin; Won Suk Lee; Mi Sun Kang; Sang-Yull Lee; Jae-Dong Lee; Yeong-Min Park
- Abstract
Background: Platelet-activating factor (PAF) has been long believed to be associated with many pathophysiological processes during septic shock. Here we present novel activities for PAF in protecting mice against LPS-mediated endotoxic shock. Principal Findings: In vivo PAF treatment immediately after LPS challenge markedly improved the survival rate against mortality from endotoxic shock. Administration of PAF prominently attenuated LPS-induced organ injury, including profound hypotension, excessive polymorphonuclear neutrophil infiltration, and severe multiple organ failure. In addition, PAF treatment protects against LPS-induced lymphocytes apoptosis. These protective effects of PAF was correlated with significantly decreases in the production of the inflammatory mediators such as TNF-α, IL-1β, IL-12, and IFN-γ, while increasing production of the anti-inflammatory cytokine IL-10 in vivo and in vitro. Conclusions: Taken together, these results suggest that PAF may protect mice against endotoxic shock via a complex mechanism involving modulation of inflammatory and anti-inflammatory mediators.
- Subjects
SEPTIC shock; PATHOLOGICAL physiology; LYMPHOCYTES; APOPTOSIS; CELL death; CYTOKINES; NEUTROPHILS; GRANULOCYTES; INFLAMMATORY mediators
- Publication
PLoS ONE, 2009, Vol 4, Issue 8, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0006503