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- Title
Assessment of the abuse potential of methamnetamine in rodents: a behavioral pharmacology study.
- Authors
Youn, Dong-Hyun; Kim, Jin Mook; Hong, Young-ki; Park, Seo-In; Lee, Jin-Moo; Kim, Young-Hoon; Park, Chang Won; Kang, Mi Sun
- Abstract
Rationale: Methamnetamine (MNA; PAL-1046) is a new psychoactive substance that acts as a full biogenic amine transporter (BAT) substrate. BAT substrates promote neurotransmitter release from the nerve terminal and can be abused as stimulants. However, scientific information on the abuse potential of methamnetamine is lacking. Objective: We evaluated the abuse liability of methamnetamine. Methods: The effective dose range of methamnetamine was determined using a climbing behavior test. The rewarding effect and reinforcing effect of the test compound were evaluated in mice by conditioned place preference (CPP) testing and self-administration (SA) testing at the selected doses. Dopamine level changes were analyzed using synaptosomes and in vivo microdialysis to investigate the effects of methamnetamine on the central nervous system. Drug discrimination experiments were used to examine the potential similarity of the interoceptive effects of methamnetamine and cocaine. Results: A significant response was observed in the climbing behavior test with 10 and 40 mg/kg intraperitoneally administered methamnetamine. In the CPP test, mice intraperitoneally administered methamnetamine (10 and 20 mg/kg) showed a significant preference for the drug-paired compartment. In the SA test, mice that intravenously received 1 mg/kg/infusion showed significant active-lever responses. Dopamine was significantly increased in synaptosomes and in in vivo microdialysis tests. Furthermore, methamnetamine showed cross-generalization with cocaine in a dose-dependent manner. Conclusions: Methamnetamine exhibits interceptive stimulus properties similar to those of cocaine and induces rewarding and reinforcing effects, suggesting its dependence liability potential.
- Subjects
PSYCHOPHARMACOLOGY; CENTRAL nervous system; REWARD (Psychology); RODENTS; NERVE endings; COCAINE; DOPAMINE
- Publication
Psychopharmacology, 2021, Vol 238, Issue 8, p2155
- ISSN
0033-3158
- Publication type
Article
- DOI
10.1007/s00213-021-05840-9