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- Title
Reduction in N2 amplitude in response to deviant drug-related stimuli during a two-choice oddball task in long-term heroin abstainers.
- Authors
Su, Bobo; Wang, Sha; Sumich, Alexander; Li, Shaomei; Yang, Ling; Cai, Yueyue; Wang, Grace
- Abstract
Rationale: Chronic heroin use can cause deficits in response inhibition, leading to a loss of control over drug use, particularly in the context of drug-related cues. Unfortunately, heightened incentive salience and motivational bias in response to drug-related cues may exist following abstinence from heroin use. Objectives: The present study aimed to examine the effect of drug-related cues on response inhibition in long-term heroin abstainers. Methods: Sixteen long-term (8-24 months) male heroin abstainers and 16 male healthy controls completed a modified two-choice oddball paradigm, in which a neutral 'chair' picture served as frequent standard stimuli; the neutral and drug-related pictures served as infrequent deviant stimuli of different conditions respectively. Event-related potentials were compared across groups and conditions. Results: Our results showed that heroin abstainers exhibited smaller N2d amplitude (deviant minus standard) in the drug cue condition compared to the neutral condition, due to smaller drug-cue deviant-N2 amplitude compared to neutral deviant-N2. Moreover, heroin abstainers had smaller N2d amplitude compared with the healthy controls in the drug cue condition, due to the heroin abstainers having reduced deviant-N2 amplitude compared to standard-N2 in the drug cue condition, which reversed in the healthy controls. Conclusions: Our findings suggested that heroin addicts still show response inhibition deficits specifically for drug-related cues after longer-term abstinence. The inhibition-related N2 modulation for drug-related could be used as a novel electrophysiological index with clinical implications for assessing the risk of relapse and treatment outcome for heroin users.
- Subjects
HEROIN abuse; RESPONSE inhibition; DRUG utilization; DRUG side effects; DEVIANT behavior; NEUTRALIZATION theory
- Publication
Psychopharmacology, 2017, Vol 234, Issue 21, p3195
- ISSN
0033-3158
- Publication type
Article
- DOI
10.1007/s00213-017-4707-5