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- Title
Statin therapy reduces oxidized low density lipoprotein level, a risk factor for stroke outcome.
- Authors
Nai-Wen Tsai; Lian-Hui Lee; Chi-Ren Huang; Wen-Neng Chang; Ya-Ting Chang; Yu-Jih Su; Yi-Fang Chiang; Hung-Chen Wang; Ben-Chung Cheng; Wei-Che Lin; Chia-Te Kung; Chih-Min Su; Yu-Jun Lin; Cheng-Hsien
- Abstract
Introduction Statins are reported to have anti-inflammatory and anti-oxidative effects aside from cholesterol-lowering effects. This study aimed to evaluate the effects of statin therapy on oxidized LDL (Ox-LDL) and the clinical outcome of patients with acute ischemic stroke (AIS). Methods This prospective study enrolled 120 patients with AIS divided in the statin (n = 55) and nonstatin (n = 65) groups. Eighty sex- and age- matched participants were recruited as risk controls. Ox-LDL was measured using a monoclonal antibody-based enzyme-linked immune-sorbent assay at different time points after AIS. The clinical outcomes were analyzed between the statin and non-statin groups. Results Plasma Ox-LDL was significantly higher in stroke patients than in the controls (P < 0.001). Plasma Ox-LDL level was significantly reduced in the statin group on day 7 and day 30 compared to the non-statin group (P < 0.01). The plasma Ox-LDL positively correlated with serum total cholesterol, LDL-cholesterol, and hemoglobin A1c (HbA1c). Among the potential risk factors, only National Institutes of Health stroke scale (NIHSS) score and Ox- LDL level on admission were independently associated with 3-month outcome. Conclusions Our study demonstrates that statin therapy reduces plasma Ox-LDL level after AIS. Plasma Ox-LDL may be a more powerful predictor than serum LDL, high-sensitivity C-reactive protein or white blood cell counts for stroke outcome. Therefore, assay of plasma Ox-LDL should be added as a predictor among the panel of conventional biomarkers in stroke outcome.
- Subjects
STATINS (Cardiovascular agents); LIPOPROTEINS; ANTICHOLESTEREMIC agents; HEMOGLOBIN polymorphisms; CEREBROVASCULAR disease patients; BIOMARKERS
- Publication
Critical Care, 2014, Vol 18, Issue 1, p1
- ISSN
1364-8535
- Publication type
Article
- DOI
10.1186/cc13695