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- Title
Benzodiazepine use and mortality of incident dialysis patients in the United States.
- Authors
Winkelmayer, W. C.; Mehta, J.; Wang, P. S.
- Abstract
Benzodiazepines and other omega-receptor agonists are frequently used for sleep and anxiety disorders. We studied the rates, correlates, and safety of individual benzodiazepines and zolpidem use from the records of 3690 patients in a national cohort of Dialysis Morbidity and Mortality Study Wave 2 data. We assessed drug utilization and an association between drug use and all-cause mortality. Overall, 14% of incident dialysis patients used a benzodiazepine or zolpidem. Women, Caucasians, current smokers, and patients with chronic obstructive pulmonary disease were more likely to use these drugs, whereas patients with cerebrovascular disease were less likely to use these drugs. In adjusted analyses, benzodiazepine or zolpidem use was associated with a 15% higher mortality rate. Chronic obstructive pulmonary disease significantly modified this association, suggesting that these patients were at higher risk. No association was found between benzodiazepine use and greater risk for hip fracture. We conclude that benzodiazepine or zolpidem use is common in incident dialysis patients and may be associated with greater mortality. Further studies are needed to elucidate the safety of these drugs in the dialysis population, which may lead to cautious and restrictive utilization of omega-receptor agonists in dialysis patients.Kidney International (2007) 72, 1388–1393; doi:10.1038/sj.ki.5002548; published online 12 September 2007
- Subjects
BENZODIAZEPINES; TRANQUILIZING drugs; LUNG diseases; HOSPITAL drug distribution systems; CEREBROVASCULAR disease
- Publication
Kidney International, 2007, Vol 72, Issue 11, p1388
- ISSN
0085-2538
- Publication type
Article
- DOI
10.1038/sj.ki.5002548