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- Title
Streptococcal pyrogenic exotoxin B antibodies in a mouse model of glomerulonephritis.
- Authors
Luo, Y.-H.; Kuo, C.-F.; Huang, K.-J.; Wu, J.-J.; Lei, H.-Y.; Lin, M. T.; Chuang, W.-J.; Liu, C.-C.; Lin, C.-F.; Lin, Y.-S.
- Abstract
Streptococcal pyrogenic exotoxin B is an extracellular cysteine protease. Only nephritis-associated strains of group A streptococci secrete this protease and this may be involved in the pathogenesis of post-streptococcal glomerulonephritis. Mice were actively immunized with a recombinant protease inactive exotoxin B mutant or passively immunized with exotoxin B antibody. Characteristics of glomerulonephritis were measured using histology, immunoglobulin deposition, complement activation, cell infiltration, and proteinuria. None of the mice given bovine serum albumin or exotoxin A as controls showed any marked changes. Immunoglobulin deposition, complement activation, and leukocyte infiltration occurred only in the glomeruli of exotoxin B-hyperimmunized mice. One particular anti-exotoxin B monoclonal antibody, 10G, was cross-reactive with kidney endothelial cells and it caused kidney injury and proteinuria when infused into mice. This cross-reactivity may be involved in the pathogenesis of glomerulonephritis following group A streptococcal infection.Kidney International (2007) 72, 716–724; doi:10.1038/sj.ki.5002407; published online 18 July 2007
- Subjects
STREPTOCOCCAL diseases; TOXIC shock syndrome toxin-1; IMMUNOGLOBULINS; GLOMERULONEPHRITIS; PROTEOLYTIC enzymes; HISTOLOGY
- Publication
Kidney International, 2007, Vol 72, Issue 6, p716
- ISSN
0085-2538
- Publication type
Article
- DOI
10.1038/sj.ki.5002407