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- Title
Human papillomavirus genotype distribution among French women with and without cervical abnormalities
- Authors
Casalegno, Jean-Sebastien; Benchaib, Mehdi; Le Bail Carval, Karine; Piaton, Eric; Mathevet, Patrice; Mekki, Yahia
- Abstract
<bold>Objective: </bold>To assess human papillomavirus (HPV) prevalence and distribution among French women with normal and pathologic cytology findings.<bold>Methods: </bold>A genomic DNA microarray assay enabling the detection of 35 different HPV genotypes was used for in vitro diagnosis, as a complement to Papanicolaou screening, to test 785 women who attended the gynecology department of a hospital in Lyon, France.<bold>Results: </bold>Pathologic and normal cytology findings were obtained for 260 (33.1%) and 302 (38.5%) of the 785 women, respectively, whereas 223 (28.4%) results were inconclusive. HPV infection and multiple infection were significantly more prevalent (P<0.001) in the population with pathologic findings (90.0% and 41.9%, respectively) than in the population with normal cytology findings (48.3% and 20.2%, respectively). Overall, the 4 most frequent HPV genotypes were HPV-16 (14.8%), HPV-53 (9.0%), HPV-31 (8.7%), and HPV-51 (7.5%), whereas HPV-18 (3.8%), HPV-6 (2.9%), and HPV-11 (0.4%) were less common. The HPV genotypes included in the quadrivalent vaccination had a prevalence of 20.6% among all women and 30.4% among those with pathologic findings.<bold>Conclusion: </bold>The present data indicate a reduced direct impact of HPV vaccination in the study population owing to a low prevalence of HPV-18 and a high prevalence of HPV-53, HPV-31, and HPV-51.
- Subjects
FRANCE; CERVICAL cancer; PAPILLOMAVIRUSES; HUMAN abnormalities; FIRE assay; MEDICAL statistics; DYSPLASIA; DNA microarrays; DISEASE prevalence; CERVIX uteri; PAPILLOMAVIRUS diseases
- Publication
International Journal of Gynecology & Obstetrics, 2011, Vol 114, Issue 2, p116
- ISSN
0020-7292
- Publication type
journal article
- DOI
10.1016/j.ijgo.2011.01.030