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- Title
The effect of acetaminophen ingestion on cortico-spinal excitability.
- Authors
Mauger, Alexis R.; Hopker, James G.
- Abstract
Acetaminophen (ACT) facilitates the inhibition of voltage-gated calcium and sodium currents, which may effect cortico-spinal excitability. Twelve subjects ingested acetaminophen or a placebo and underwent transcranial magnetic stimulation to assess the motor evoked potential (MEP), and cortical silent period (CSP). ACT significantly increased MEP response ( P > 0.05) but had no effect on CSP ( P > 0.05). This indicates that ACT increases MEP and should be controlled for in studies where these measures are of interest.
- Subjects
ACETAMINOPHEN; MOTOR cortex; TRANSCRANIAL magnetic stimulation; FATIGUE (Physiology); ANALGESICS
- Publication
Canadian Journal of Physiology & Pharmacology, 2013, Vol 91, Issue 2, p187
- ISSN
0008-4212
- Publication type
Article
- DOI
10.1139/cjpp-2012-0213