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- Title
Synthesis, Crystal Structure and NMR Assignments of 17β-Acetoxy-4,5-secoandrost-3-yn-5-one.
- Authors
Labra-Vázquez, Pablo; Romero-Ávila, Margarita; Flores-Álamo, Marcos; Iglesias-Arteaga, Martín
- Abstract
The synthesis, crystal structure and NMR characterization of 17β-acetoxy-4,5-secoandrost-3-yn-5-one ( 3) are described. The title compound which crystallizes in the orthorhombic system with a space group P222, was obtained by Eschenmoser-Tanabe fragmentation of the mixture of epimeric epoxides 17β-acetoxy-4,5-epoxy-5α-androstan-3-one ( 2a) and 17β-acetoxy-4,5-epoxy-5β-androstan-3-one ( 2b). Graphical Abstract: The synthesis, crystal structure and NMR assignments of 17β-acetoxy-4,5-secoandrost-3-yn-5-one is described.[Figure not available: see fulltext.]
- Subjects
CRYSTAL structure research; NUCLEAR magnetic resonance; SPACE groups; FRAGMENTATION reactions; X-ray diffraction; EPOXY compounds
- Publication
Journal of Chemical Crystallography, 2013, Vol 43, Issue 11, p605
- ISSN
1074-1542
- Publication type
Article
- DOI
10.1007/s10870-013-0466-2