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- Title
Update on triple-negative breast cancer disparities for the United States: A population-based study from the United States Cancer Statistics database, 2010 through 2014.
- Authors
Scott, Lia C.; Mobley, Lee R.; Kuo, Tzy‐Mey; Il'yasova, Dora; Kuo, Tzy-Mey
- Abstract
<bold>Background: </bold>Triple-negative breast cancer (TNBC) has been associated with a more aggressive histology, poorer prognosis, and nonresponsiveness to hormone therapy. It is imperative that cancer research identify factors that drive disparities and focus on prevention.<bold>Methods: </bold>Using the United States Cancer Statistics database, the authors examined differences between TNBCs compared with all other breast cancers with regard to age, race/ethnicity, and stage at diagnosis.<bold>Results: </bold>A total of 1,151,724 cases of breast cancer were identified from 2010 through 2014, with the triple-negative phenotype accounting for approximately 8.4% of all cases. In unadjusted analyses, non-Hispanic black women (odds ratio [OR], 2.27; 95% CI, 2.23-2.31) and Hispanic women (OR, 1.22; 95% CI, 1.19-1.25) had higher odds of diagnosis when compared with non-Hispanic white women. Women aged <40 years had the highest odds of diagnosis compared with women aged 50 to 64 years (OR, 1.95; 95% CI, 1.90-2.01). Diagnosis at American Joint Committee on Cancer stage III and beyond conferred higher odds of the diagnosis of TNBC (OR for stage III, 1.69 [95% CI, 1.68-1.72]; and OR for stage IV, 1.47 [95% CI, 1.43-1.51]). Results varied slightly in adjusted analyses.<bold>Conclusions: </bold>The results of the current study demonstrated that there is a significant burden of disease in TNBC diagnosed among women of color, specifically non-Hispanic black women, and younger women. Additional studies are needed to determine drivers of disparities between race, age, and stage of disease at diagnosis.
- Subjects
UNITED States; CANCER statistics; BREAST cancer; TRIPLE-negative breast cancer; WOMEN of color; HEALTH equity; EPIDEMIOLOGY of cancer
- Publication
Cancer (0008543X), 2019, Vol 125, Issue 19, p3412
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/cncr.32207