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- Title
Vaccination with a Haemophilus influenzae Type b Conjugate Vaccine Reduces Oropharyngeal Carriage of H. influenzae Type b among Gambian Children.
- Authors
Adegbola, Richard A.; Mulholland, E. Kim; Secka, Ousman; Jaffar, Shabbar; Greenwood, Brian M.
- Abstract
The effect of a Haemophilus influenzae type b (Hib) polyribosylribitol phosphate-tetanus toxoid conjugate vaccine (Hib/PRP-T) on oropharyngeal carriage of Hib was studied during an efficacy trial in Gambian infants. Children were vaccinated with Hib/PRP-T and diphtheria-tetanus toxoids-pertussis (DTP) or DTP alone at ages 2, 3, and 4 months. Groups of 1000 children aged 1–2 years were studied each year for 4 years. Hib was detected by production of a halo on antiserum agar plates. Carriage was significantly lower among children fully vaccinated with Hib/PRP-T given with DTP (4.4%; 95% confidence interval [CI], 3.8%–5.7%) than among children fully vaccinated with DTP alone (11.0%; 95% CI, 8.9%–13.0%) (protective effect adjusted by year = 60%; 95% CI, 44%–72%; P < .001). Hib carriage varied by year among nonvaccinated children. Hib conjugate vaccines are likely to produce a herd protective effect in underdeveloped communities, as recorded in Europe and the United States.
- Publication
Journal of Infectious Diseases, 1998, Vol 177, Issue 6, p1758
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1086/517440