We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
A Live Attenuated Bovine Parainfluenza Virus Type 3 Vaccine Is Safe, Infectious, Immunogenic, and Phenotypically Stable in Infants and Children.
- Authors
Karron, Ruth A.; Wright, Peter F.; Hall, Susan L.; Makhene, Mamodikoe; Thompson, Juliette; Burns, Barbara A.; Tollefson, Sharon; Steinhoff, Mark C.; Wilson, Modena H.; Harris, Denos O.; Clements, Mary Lou; Murphy, Brian R.
- Abstract
The safety, infectivity, immunogenicity, transmissibility, and phenotypic stability of an intranasal bovine parainfluenza virus type 3 (BPIV-3) candidate vaccine was evaluated in a randomized, double-blind, placebo-controlled trial. Of human parainfluenza virus type 3 (HPIV-3)-seronegative children, 92% were infected, and 92% developed a serum hemagglutination-inhibiting (HAI) antibody response to BPIV-3 and 61% to HPIV-3. Geometric mean HAI titers were 1:40 to BPIV-3 and 1:16 to HPIV-3. In studies to evaluate vaccine transmissibility, none of 14 placebo recipients in close contact with 14 vaccinees shed BPIV-3. BPIV-3 isolates from seronegative vaccinees retained the attenuation phenotype when tested in rhesus monkeys. Although it is difficult to evaluate the safety and immunogenicity of such a vaccine in an open population of children who frequently become infected with HPIV-3, it appears that the live BPIV-3 vaccine is attenuated, infectious, immunogenic, poorly transmissible, and phenotypically stable and warrants further evaluation as a candidate vaccine in infants and children.
- Publication
Journal of Infectious Diseases, 1995, Vol 171, Issue 5, p1107
- ISSN
0022-1899
- Publication type
Article