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- Title
Chemoprophylaxis for Neisseria meningitidis in an isolated Arctic community.
- Authors
Nicolle, L E; Postl, B; Kotelewetz, E; Remillard, F; Bourgault, A M; Albritton, W; Harding, G K; Ronald, A
- Abstract
Community chemoprophylaxis with a regimen of sequential minocycline/rifampin (adults) or rifampin alone (children [less than 12 years of age]) was undertaken in a remote Arctic community one year after an outbreak of meningitis due to Neisseria meningitidis serogroup B. Nasopharyngeal carriage rates of N. meningitidis before prophylaxis were 32.4% in Inuit (Eskimos) and 6% in Caucasians, with maximal carriage (44.8%) in adolescents. Serogroup B accounted for 63.9% of all isolates before prophylaxis. One week after prophylaxis, the nasopharyngeal carriage rates were 0.8% in Inuit who had received prophylaxis and 33.3% in those who had not received prophylaxis (P less than 0.005). This reduction persisted at nine weeks after prophylaxis, when carriage rates were 1.2% in those who had received prophylaxis and 22.6% in individuals who had not received prophylaxis. Of the strains obtained before prophylaxis, 7.8% were sulfadiazine-resistant, whereas 35% of all isolates obtained from prophylaxis were sulfadiazine-resistant. Rifampin- or minocycline-resistant strains were not identified either before or after prophylaxis.
- Publication
Journal of Infectious Diseases, 1982, Vol 145, Issue 2, p103
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/145.1.103