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- Title
Immunologic Studies of Disseminated Infection with Aspergillus fumigatus in the Nude Mouse.
- Authors
Williams, Dwight M.; Weiner, Marc H.; Drutz, David J.
- Abstract
Immunity to infection with Aspergillus fumigatus conidia was studied in the athymic nude (nu/nu) mouse. The intratracheal, intravenous, and intraperitoneal routes of infection were used. Nu/nu mice were not significantly more susceptible than their heterozygous (nu/+) littermates. However, only nu/+ animals could be protected by prior immunization and developed positive, A. fumigatus-specific skin tests. Protection could be transferred to nu/nu recipients by immune glass-adherent cells. Thus, immunity to invasive aspergillus infection is multifactorial and depends on a glass-adherent cell population and T-cells.
- Publication
Journal of Infectious Diseases, 1981, Vol 143, Issue 5, p726
- ISSN
0022-1899
- Publication type
Article