We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Proopiomelanocortin and energy balance: insights from human and murine genetics.
- Authors
Coll, Anthony P; Farooqi, I Sadaf; Challis, Benjamin G; Yeo, Giles S H; O'Rahilly, Stephen
- Abstract
Proopiomelanocortin (POMC) undergoes extensive and tissue-specific posttranslational processing to yield a range of biologically active peptides. Historically, the most clearly defined roles of these peptides are in the control of adrenal steroidogenesis by corticotroph-derived ACTH and skin pigmentation by alphaMSH. However, a rapidly expanding body of work has established that POMC-derived peptides synthesized in neurons of the hypothalamus play a central role in the control of energy homeostasis. We review how inherited abnormalities in POMC synthesis and processing and defects in the action of POMC-derived peptides in both humans and mice have helped shape our current understanding of the importance of the melanocortin system in human energy balance.
- Publication
Journal of Clinical Endocrinology & Metabolism, 2004, Vol 89, Issue 6, p2557
- ISSN
0021-972X
- Publication type
journal article
- DOI
10.1210/jc.2004-0428