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- Title
Respiratory viruses and the inflammasome: The double-edged sword of inflammation.
- Authors
Waldstein, Kody A.; Varga, Steven M.
- Abstract
Individuals actively infected with respiratory viruses, such as influenza A virus (IAV), respiratory syncytial virus (RSV), and coronaviruses, transmit by shedding droplets containing live virus while coughing, sneezing, or talking. NLRP3-Inflammasome Inhibition during Respiratory Virus Infection Abrogates Lung Immunopathology and Long-Term Airway Disease Development. In the lung, K SP + sp efflux and NLRP3 inflammasome activation drives ventilator-induced lung injury, a common treatment in patients with significantly reduced lung function following severe respiratory infection [[47]]. Chemical inhibition of NLRP3 in vivo revealed that early in infection, NLRP3 inflammasome activation is protective and indispensable to control IAV replication and lung pathology.
- Subjects
INFLAMMASOMES; INTERFERON receptors; PLANT viruses; NEUROENDOCRINE cells; RESPIRATORY syncytial virus infections; HUMAN metapneumovirus infection; NATURAL immunity
- Publication
PLoS Pathogens, 2022, Vol 18, Issue 12, p1
- ISSN
1553-7366
- Publication type
Article
- DOI
10.1371/journal.ppat.1011014