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- Title
Resveratrol Does Not Protect from Ischemia-Induced Acute Kidney Injury in an in Vivo Rat Model.
- Authors
Bienholz, Anja; Mae Pang, Rahel; Guberina, Hana; Rauen, Ursula; Witzke, Oliver; Wilde, Benjamin; Petrat, Frank; Feldkamp, Thorsten; Kribben, Andreas
- Abstract
Background/Aims: The natural polyphenol resveratrol (RSV) has been shown to ameliorate ischemia/reperfusion (I/R)-induced damage. Therefore, a rat model of I/R-induced AKI equipped with intensive monitoring was utilized to examine direct renal protection by RSV in vivo. Methods: AKI was induced by bilateral renal clamping (45 min) followed by reperfusion (3 h). Solvent-free RSV was continuously infused intravenously (0.056 and 0.28 mg/kg) in a total volume of 7 ml/kg/h starting from 30 min before renal clamping. At a mean arterial blood pressure below 70 mmHg for more than 5 min, bolus injections of 0.5 ml 0.9% NaCl solution were administered repetitively (max. 5 ml/kg/h). Results: No differences could be found between normoxic control groups with/without RSV. Bilateral renal clamping and subsequent reperfusion caused a progressive rise in creatinine, cystatin C, and CK, a decrease in cellular ATP content and diuresis. Infusion of RSV increased sirtuin 1 expression after ischemia/reperfusion and was associated with decreased blood pressure during ischemia and early reperfusion accompanied by an increased requirement of bolus injections as well as with increased expression of TNFα. Conclusion: RSV did not exert protective effects on I/Rinduced AKI in the present short-term in vivo rat model. The lack of protection is potentially connected to aggravation of blood pressure instability.
- Subjects
RESVERATROL; ISCHEMIA; KIDNEY injuries; ANIMAL models in research; REPERFUSION injury
- Publication
Kidney & Blood Pressure Research, 2018, Vol 42, Issue 6, p1090
- ISSN
1420-4096
- Publication type
Article
- DOI
10.1159/000485606