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- Title
EFFICACY OF THE CERVICAL PESSARY COMBINED WITH VAGINAL PROGESTERONE FOR THE PREVENTION OF SPONTANEOUS PRETERM BIRTH.
- Authors
Daskalakis, G.; Zacharakis, D.; Theodora, M.; Antsaklis, P.; Sindos, M.; Asimakopoulos, G.; Maritsa, V.; Loutradis, D.; Antsaklis, A.
- Abstract
Introduction: Aim of this study was to evaluate the safety and efficacy of the combined treatment of cervical pessary and endovaginal progesterone for the prevention of spontaneous preterm birth (SPB) in women with a short cervical length between 20 to 24 weeks of gestation. Materials and Methods: Prospective study of women with a singleton pregnancy and a sonographically detected mid-trimester cervical length ≤25mm. The primary outcome measure was spontaneous delivery before 34 weeks (238 days) of gestation. Results: The study sample consisted of 90 women with a mean cervical length of 14.2 mm (SD=6.5 mm). 34.4% of the women had at least one risk factor for SPB. 7.8% of the women delivered preterm before 34 weeks of gestation, and 25.6% before 37 weeks. Neonatal death occurred in 2.2% of the cases. Women with lower body mass index (BMI) values, history of preterm delivery and the number of 2nd trimester miscarriages were independently associated with delivery before 34 weeks. Conclusion: Combination of vaginal progesterone and cervical pessary for the prevention of SPB in women with a short cervix is safe and well tolerated. This therapy was associated with a pregnancy prolongation, reduced prematurity rate and a low rate of perinatal complications.
- Subjects
SERBIA; PREMATURE infants; CONFERENCES &; conventions; PESSARIES; PROGESTERONE; VAGINAL medication; TREATMENT effectiveness; PREVENTION
- Publication
Journal of Perinatal Medicine, 2017, Vol 45, p140
- ISSN
0300-5577
- Publication type
Article
- DOI
10.1515/jpm-2017-3001