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- Title
Assignment<FOOTREF>[sup 1] </FOOTREF> of the serologically defined colon cancer antigen 1 gene (SDCCAG1) to human chromosome band 14q22 by in situ hybridization.
- Authors
Carbonnelle, D.; Liehr, T.; Jacquot, C.; Masson, D.; Lustenberger, P.; Denis, M. G.; Roussakis, C.
- Abstract
This article focuses on the localization of serologically defined colon cancer antigen 1 gene (SDCCAG 1) to human chromosome band 14q22 by in situ hybridization. A human Non Small Cell Lung Carcinoma cell line was treated in vitro with a terminal differentiation inducer, YT1. Differentially, expressed genes were detected by using the differential display strategy. DNA sequencing was performed to identify one of the identified cDNAs as the SDCCAG 1 gene, previously named NY-CO-1. This gene codes for a novel human antigen, recently, identified the immunoscreening of colon cancer cDNA expression libraries with autologous sera. Analysis of the deduced amino acid sequence indicated the presence of a nuclear targeting signal. Although the function of this gene remains to be elucidated, it is tempting to speculate that SDCCAG1 codes for a nuclear protein that may function as a tumor suppressor gene.
- Subjects
COLON cancer; GENE mapping; AMINO acid sequence; HUMAN chromosomes; IN situ hybridization; GENETICS
- Publication
Cytogenetics & Cell Genetics, 1999, Vol 86, Issue 3/4, p248
- ISSN
0301-0171
- Publication type
Article
- DOI
10.1159/000015352