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- Title
Strong Purifying Selection in Transmission of Mammalian Mitochondrial DNA.
- Authors
Stewart, James Bruce; Freyer, Christoph; Elson, Joanna L.; Wredenberg, Anna; Cansu, Zekiye; Trifunovic, Aleksandra; Larsson, Nils-Göran
- Abstract
We have used a genetic mouse model with a proofreading-deficient mitochondrial polymerase to mutagenize the mouse mitochondrial genome. The inherited mutations are subject to rapid purifying selection against amino acid substitutions.
- Subjects
MITOCHONDRIAL DNA; AMINO acids; MAMMALS; VERTEBRATES; AMINO compounds; ORGANIC acids; MYCOSPORINE-like amino acids
- Publication
PLoS Biology, 2008, Vol 6, Issue 1, pe10
- ISSN
1544-9173
- Publication type
Article
- DOI
10.1371/journal.pbio.0060010