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- Title
Simultaneous MR thermometry and acoustic radiation force imaging using interleaved acquisition.
- Authors
de Bever, Joshua T.; Odéen, Henrik; Hofstetter, Lorne W.; Parker, Dennis L.
- Abstract
Purpose: A novel and practical method for simultaneously performing MR acoustic radiation force imaging (ARFI) and proton resonance frequency (PRF)‐shift thermometry has been developed and tested. This could be an important tool for evaluating the success of MR‐guided focused ultrasound procedures for which MR‐thermometry measures temperature and thermal dose and MR‐ARFI detects changes in tissue mechanical properties. Methods: MR imaging was performed using a gradient recalled echo segmented echo‐planar imaging pulse sequence with bipolar motion encoding gradients (MEG). Images with ultrasound pulses (ON) and without ultrasound pulses (OFF) during the MEG were interleaved at the repetition time (TR) level. ARFI displacements were calculated by complex subtraction of ON–OFF images, and PRF temperature maps were calculated by baseline subtraction. Evaluations in tissue‐mimicking phantoms and ex vivo porcine brain tissue were performed. Constrained reconstruction improved the temporal resolution of dynamic measurements. Results: Simultaneous maps of displacement and temperature were acquired in 2D and 3D while keeping tissue heating < 1°C. Accuracy of the temperature maps was comparable to the standard PRF sequence. Using constrained reconstruction and subsampled k‐space (R = 4.33), 3D simultaneous temperature and displacement maps can be acquired every 4.7 s. Conclusion: This new sequence acquires simultaneous temperature and displacement maps with minimal tissue heating, and can be applied dynamically for monitoring tissue mechanical properties during ablation procedures. Magn Reson Med 79:1515–1524, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
- Publication
Magnetic Resonance in Medicine, 2018, Vol 79, Issue 3, p1515
- ISSN
0740-3194
- Publication type
Article
- DOI
10.1002/mrm.26827