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- Title
Relationship between Urokinase-Type Plasminogen Receptor, Interleukin-8 Gene Expression and Clinicopathological Features in Gastric Cancer.
- Authors
Kyung Hee Lee; Sung Hwa Bae; Jae Lyun Lee; Myung Soo Hyun; Sang Hoon Kim; Sun Kyo Song; Hee Sun Kim
- Abstract
Objective: The serine protease urokinase-type plasminogen (uPA) and its receptor (uPAR) appear to have a major function in tumor invasion and metastasis. Interleukin-8 (IL-8) acts as an angiogenic factor in solid cancer. The purpose of this study was to determine whether the expression of IL-8 and the uPAR gene correlates with clinicopathological parameters in human gastric carcinoma. Methods: We examined the expression of uPAR mRNA and IL-8 mRNA using Northern blot analysis and RT-PCR in 35 gastric carcinomas and the surrounding normal mucosa. Macroscopic and histopathological tumor findings and survival rates were obtained from the patient records. Results: uPAR and IL-8 mRNA expression levels were higher in most neoplasms compared to the corresponding normal mucosal tissue. A correlation between uPAR and IL-8 expression in tumors was observed (r = 0.447, p < 0.01). uPAR mRNA expression in the tumors correlated well with lymph node metastasis (p < 0.02), and its stage (p < 0.01). The IL-8 MRNA expression in the tumors correlated with diffuse-type gastric cancer (p < 0.05). The survival rates of patients with tumors displaying high uPAR expression levels were significantly lower (p < 0.04) than those of patients without uPAR expression, but patients with IL-8 expression only showed a tendency to a lower survival rate. Conclusion: These results suggest that uPAR and IL-8 may be important prognostic factors in human gastric carcinomas. Copyright © 2004 S. Karger AG, Basel
- Subjects
STOMACH cancer; PLASMINOGEN activators; GENE expression; INTERLEUKIN-8; SERINE proteinases; UROKINASE; PLASMINOGEN
- Publication
Oncology, 2004, Vol 66, Issue 3, p210
- ISSN
0030-2414
- Publication type
Article
- DOI
10.1159/000077997