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- Title
O-GlcNAc signalling: implications for cancer cell biology.
- Authors
Slawson, Chad; Hart, Gerald W.
- Abstract
O-GlcNAcylation is the covalent attachment of β-D-N-acetylglucosamine (GlcNAc) sugars to serine or threonine residues of nuclear and cytoplasmic proteins, and it is involved in extensive crosstalk with other post-translational modifications, such as phosphorylation. O-GlcNAcylation is becoming increasing realized as having important roles in cancer-relevant processes, such as cell signalling, transcription, cell division, metabolism and cytoskeletal regulation. However, currently little is known about the specific roles of aberrant O-GlcNAcylation in cancer. In this Opinion article, we summarize the current understanding of O-GlcNAcylation in cancer and its emerging functions in transcriptional regulation at the level of chromatin and transcription factors.
- Subjects
GLUCOSAMINE; SERINE; NUCLEAR proteins; PHOSPHORYLATION; CELL division; CELL metabolism; CANCER; BIOCHEMISTRY; CELLULAR signal transduction; DRUG therapy; COMPARATIVE studies; GENES; PHENOMENOLOGY; RESEARCH methodology; MEDICAL cooperation; METABOLISM; RESEARCH; TRANSFERASES; TUMORS; EVALUATION research; NEOPLASTIC cell transformation
- Publication
Nature Reviews Cancer, 2011, Vol 11, Issue 9, p678
- ISSN
1474-175X
- Publication type
research
- DOI
10.1038/nrc3114