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- Title
Oncocytic adrenocortical adenoma mixed with a myelolipoma: from surgery outcome to adrenal congenital hyperplasia-related menstrual cycle disturbances.
- Authors
Şandru, Florica; Petca, Aida; Gheorghe, Ana-Maria; Petrova, Eugenia; Ghemigian, Adina; Petca, Răzvan-Cosmin; Carsote, Mara; Dumitraşcu, Mihai-Cristian; Nistor, Claudiu
- Abstract
The most common cause of congenital adrenal hyperplasia (CAH) is 21-hydroxylase deficiency. Our purpose is to introduce a mostly unique case of CAH that associated an adrenal tumor in relationship with this enzymatic defect. A 27-year-old female was diagnosed with salt-wasting CAH as a neonate, and she was under glucocorticoid substitution treatment ever since. At the age of 22 years old, she complained of diffuse abdominal pain; hence, a large right adrenal tumor of 5.5 cm was detected. She was suffering from secondary amenorrhea ever since menarche at 15; she was under poor glucocorticoid substitution (prednisone 10 mg/day). The patient was switched to 15 mg hydrocortisone and 0.5 mg dexamethasone daily. At the eight-month follow-up, she had regular menstrual cycles, but seemed mildly overtreated. The adrenal mass required surgical removal which she delayed for three years. An adrenocortical oncocytic neoplasm, without criteria for malignancy, associated with a myeloma component, was postoperatively confirmed. She continued glucocorticoids replacement, with menses surveillance. To our aware, only a few similar cases have been reported so far.
- Subjects
MENSTRUATION disorders; MENSTRUAL cycle; ADRENAL tumors; ADRENOGENITAL syndrome; ADENOMA; MENSTRUATION; HEMATOPOIETIC stem cell transplantation
- Publication
Obstetrică şi Ginecologie, 2024, Vol 72, Issue 1, p22
- ISSN
1220-5532
- Publication type
Article