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- Title
Assessing medication effects in the MTA study using neuropsychological outcomes.
- Authors
Epstein, Jeffery N.; Keith Conners, C.; Hervey, Aaron S.; Tonev, Simon T.; Eugene Arnold, L.; Abikoff, Howard B.; Elliott, Glen; Greenhill, Laurence L.; Hechtman, Lily; Hoagwood, Kimberly; Hinshaw, Stephen P.; Hoza, Betsy; Jensen, Peter S.; March, John S.; Newcorn, Jeffrey H.; Pelham, William E.; Severe, Joanne B.; Swanson, James M.; Wells, Karen; Vitiello, Benedetto
- Abstract
Background: While studies have increasingly investigated deficits in reaction time (RT) and RT variability in children with attention deficit/hyperactivity disorder (ADHD), few studies have examined the effects of stimulant medication on these important neuropsychological outcome measures. Methods: 316 children who participated in the Multimodal Treatment Study of Children with ADHD (MTA) completed the Conners’ Continuous Performance Test (CPT) at the 24-month assessment point. Outcome measures included standard CPT outcomes (e.g., errors of commission, mean hit reaction time (RT)) and RT indicators derived from an Ex-Gaussian distributional model (i.e., mu, sigma, and tau). Results: Analyses revealed significant effects of medication across all neuropsychological outcome measures. Results on the Ex-Gaussian outcome measures revealed that stimulant medication slows RT and reduces RT variability. Conclusions: This demonstrates the importance of including analytic strategies that can accurately model the actual distributional pattern, including the positive skew. Further, the results of the study relate to several theoretical models of ADHD.
- Subjects
DRUG side effects; ATTENTION-deficit hyperactivity disorder; JUVENILE diseases; STIMULANTS; NEUROPSYCHOLOGY; THERAPEUTICS
- Publication
Journal of Child Psychology, 2006, Vol 47, Issue 5, p446
- ISSN
0021-9630
- Publication type
Article
- DOI
10.1111/j.1469-7610.2005.01469.x