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- Title
Chromosome level genome assembly of the Etruscan shrew Suncus etruscus.
- Authors
Bukhman, Yury V.; Meyer, Susanne; Chu, Li-Fang; Abueg, Linelle; Antosiewicz-Bourget, Jessica; Balacco, Jennifer; Brecht, Michael; Dinatale, Erica; Fedrigo, Olivier; Formenti, Giulio; Fungtammasan, Arkarachai; Giri, Swagarika Jaharlal; Hiller, Michael; Howe, Kerstin; Kihara, Daisuke; Mamott, Daniel; Mountcastle, Jacquelyn; Pelan, Sarah; Rabbani, Keon; Sims, Ying
- Abstract
Suncus etruscus is one of the world’s smallest mammals, with an average body mass of about 2 grams. The Etruscan shrew’s small body is accompanied by a very high energy demand and numerous metabolic adaptations. Here we report a chromosome-level genome assembly using PacBio long read sequencing, 10X Genomics linked short reads, optical mapping, and Hi-C linked reads. The assembly is partially phased, with the 2.472 Gbp primary pseudohaplotype and 1.515 Gbp alternate. We manually curated the primary assembly and identified 22 chromosomes, including X and Y sex chromosomes. The NCBI genome annotation pipeline identified 39,091 genes, 19,819 of them protein-coding. We also identified segmental duplications, inferred GO term annotations, and computed orthologs of human and mouse genes. This reference-quality genome will be an important resource for research on mammalian development, metabolism, and body size control.
- Publication
Scientific Data, 2024, Vol 11, Issue 1, p1
- ISSN
2052-4463
- Publication type
Article
- DOI
10.1038/s41597-024-03011-x